Dr. Srinivas Chakravarthy, BioCAT beamline scientist, prepares a SEC-MALS-SAXS experiment on RNA elements from the SARS-CoV-2 virus.
Small-angle solution x-ray scattering and biochemical characterization studies at the BioCAT are being used to study the structure of portions of RNA from the SARS-CoV-2 virus. This RNA contains the genetic instructions the virus uses to replicate itself. These experiments are de-signed to see how these structures change when they interact with selected small molecules that are potential drug candidates. This work is a collaboration between Blanton Tolbert (Department of Chemistry, Case Western Reserve University), Amanda Hargrove (Duke University), Srinivas Chakravarthy (Illinois Institute of Technology, pictured above) and a NMR consortium coordinated by Harald Schwalbe at the Goethe University (Germany).