Everything BioSAXS 8 Workshop Wrap-Up

BioCAT held its eight intensive HOW-TO course in BioSAXS from 6/21/22-6/24/22 with 36 remote participants. There were four days of lectures and hands-on software tutorials on the basics of BioSAXS data collection and processing from expert practitioners in the field. Participants could elect to mail in samples for data collection prior to the course, and roughly half of them sent research samples and were able to analyze their own data as part of the workshop.
Some of the participants and instructors at the Everything BioSAXS 8 Workshop.

BioCAT held its eighth BioSAXS training course from 6/21/22-6/24/22. There were 36 remote participants and 8 instructors. The workshop was held entirely online, via Zoom, for ~5 hours each day. Before the workshop started, participants were able to mail samples to BioCAT for SAXS data collection. This data was then sent to them, and they were able to analyze it as part of the workshop.

Day one started off with an excellent overview of the basic physics of SAXS and what kind of information you can obtain from the technique by Dr. Richard Gillilan (BioSAXS beamline, CHESS). This was followed by a talk from …

more ...

Multiscale Structural and Functional Studies for Striated Muscle Workshop

To promote the use of two NIH P30 Centers that are National Resources for the study of striated muscle; the Biophysics Collaborative Access Team (BioCAT: funded by NIGMS) at Argonne National Laboratory and the Center for Translational Muscle Research (CTMR: funded by NIAMS) are offering Multiscale Structural and Functional Studies for Striated Muscle workshop following the Myofilament Meeting in Madison Wisconsin.

The goal of this workshop is to inform investigators about the resources and expertise that these two Centers can provide, and to discuss what other resources and services would be most useful. The workshop will take place on May 24th from 1:30 pm to 4 pm at Madison Monona Terrace. See the schedule below for details.

Registration

There is no cost associated with the workshop, but registration is highly encouraged for administrative purposes. How to register:

https://www.eventbrite.com/e/biocatctmr-workshop-tickets-325287903877

For questions, please contact Weikang Ma (wma6@iit.edu) or Michael Regnier (mregnier@uw.edu).

Tentative schedule, May 24th 2022

1:30 pm Introduction to CTMR - Mike Regnier
1:50 pm Scientific missions of BioCAT - Weikang Ma
2:15 pm Break + Open Discussion
2:30 pm Modeling protein structure dynamics with MD simulations - Matt Childers
3 …
more ...

Register for Everything BioSAXS 8: Getting started in biological small-angle x-ray solution scattering

BioCAT is offering its eighth intensive HOW-TO course in BioSAXS. Students will have four days of virtual lectures and hands-on software tutorials on the basics of BioSAXS data collection and processing from expert practitioners in the field. Students will also be able to mail in samples for data collection on the BioCAT beamline (Sector 18 at the APS) before the course, and there will be time during the workshop to get help with analysis of their own data.

The course will take place from 6/21/22 to 6/24/22 and is entirely virtual (via Zoom). See the schedule below for details.

Registration

All participants this year will be remote participants. The course will provide a virtual set of lectures and tutorials via Zoom, and participants will be able to mail in samples for SAXS data collection at BioCAT the week before the workshop. Participants will be able to ask questions during both lectures and tutorials, and will have time to get help with analysis of the data collected from their mail-in samples. They will also receive downloads of all course materials, including lecture slides and tutorials.

There is no cost associated with the workshop, but initial registration …

more ...

Dr. Max Watkins joins the BioCAT team

We are pleased to announce that Dr. Maxwell (Max) Watkins has recently joined BioCAT as a beamline scientist. Max got his B.S. degree in Biochemistry from Lehigh University, and his Ph.D in Chemistry from Princeton University. Much of his Ph.D. work was done at Cornell University after Prof. Nozomi Ando, his Ph.D. supervisor, moved her lab from Princeton to Cornell. His Ph.D. work involved extensive SAXS and cryo-EM studies of flexible systems. During his studies he has acquired a strong background in biochemistry and structural biology. He is extremely experienced in standard SAXS data collection and analysis techniques, including SEC-SAXS, and has used SAXS to study challenging light sensitive and anaerobic systems. Max is a great addition to the BioCAT team, and will eventually take over running most of the standard SAXS program at BioCAT. He will also be a regular participant in our SAXS coffee hours, so please drop by and say hi when you have the chance. You can find Max’s contact info on our Contact page.

Max replaces Dr. Srinivas Chakravarthy, who left BioCAT for exciting new opportunities in industry in August 2021. We are deeply appreciative of all …

more ...

BioCAT virtual town hall meeting on March 15 to discuss the impact of APS-U

Starting April 17, 2023 the APS will be down for a year to undergo a major upgrade, including rebuilding the accelerator and storage ring (“APS-U”). Following this upgrade, APS operations will restart in April 2024, though it may be several more months before all the beamlines are running again. Once completed, the new APS-U ring will provide about 100 times greater brightness than is currently available. This will provide both an increase in flux and a reduced focus size for the APS ID beamlines, including BioCAT.

BioCAT invites you to join us for a virtual town hall on March 15th to discuss the impact of APS-U on BioCAT and our user community. The purpose of this town hall is to provide an overview of the planned upgrade and its impact on, and benefits for, the BioCAT community. We also will present our plans to facilitate experiments for our users at other synchrotrons during the dark period. The town hall will consist of short presentations by BioCAT staff followed by an open-ended question and answer period. No registration is required.

Update

The presentations from the town hall and more information about APS-U and BioCAT can be found …

more ...

BioCAT Director Thomas C. Irving Honored as American Association for the Advancement of Science Fellow

BioCAT director and Illinois Institute of Technology biology and physics professor Thomas C. Irving has been named a fellow of the American Association for the Advancement of Science. Irving is being honored for “distinguished contributions to the field of muscle diffraction and enabling the fields of synchrotron fiber diffraction and biological small angle scattering.” He is among the 564 scientists, engineers, and innovators spanning 24 scientific disciplines being recognized for their scientifically and socially distinguished achievements in this year’s AAAS fellows class.

AAAS is the world’s largest general scientific society, and publisher of the Science family of journals. Fellows are nominated each year by current AAAS fellows and steering groups of the association’s 24 sections representing each scientific discipline.

“It’s gratifying,” Irving says of being named an AAAS fellow, which is a lifetime designation. “It acknowledges all the work I’ve done over the years, and it feels good to be recognized by my peers.”

Over the course of his career, Irving has become an international leader in the use of small-angle X-ray diffraction, which allows scientists to study molecular-level information in tissue to further understand illnesses such as heart disease, cancer, and neurodegenerative diseases including …

more ...

New EIGER2 XE 9M Detector Commissioned

We are a pleased to announce the delivery and initial commissioning (November 16 2021) of our new $1.8M, Dectris EIGER2 XE 9M pixel array detector which replaces our Pilatus3 X 1M detector after 7 years of reliable service. This state-of-the-art detector has dead-time free readout and a larger active area (233 x 245 mm2 vs. 169 x 180 mm2), much smaller pixels (75 μm vs. 172 μm) and faster frame rate (550 Hz vs 500 Hz) than the Pilatus detector. The larger area of the EIGER2 will extend the maximum q in macromolecular SAXS experiments in the standard configuration from ~0.35 Å-1 to ~0.50 Å-1. More excitingly, the combination of large active area and high spatial resolution of the EIGER2 detector will allow using one 3 m camera length for the majority of muscle diffraction experiments providing resolution of fine details on the meridian at low angles as well as recording the important 2.7 nm actin and 2.8 nm myosin meridional reflections at the same time. This will significantly increase the information content of our experiments, improve efficiency by minimizing need to change camera lengths and raise overall productivity. The lack …

more ...

SAXS Coffee Hour

BioCAT runs a SAXS coffee hour every two weeks on Mondays at 2 pm CDT. These virtual SAXS coffee hours are informal Zoom hangouts with the SAXS beamline scientists, where you can stop in and chat about whatever’s on your mind. They’re a great way to get help with your data analysis, start planning your next experiment, learn what’s new at the beamline, and more. They’re also a chance to chat with and learn from other BioCAT users. To receive announcements and the Zoom link for our coffee hour sign up for our mailing list.

more ...

MuscleX 2 Workshop Wrap-Up

BioCAT held its second MuscleX workshop May 20-May 21. This took the form of a two-day virtual symposium with 200 registrants and 149 attendees. The goal was to explore and celebrate the current state of muscle research using synchrotron radiation with 11 speakers from all over the world. There were lively discussions between the speakers and attendees in breakout rooms. Videos of most lectures will be made available on the BioCAT YouTube channel once editing is finished.
Participants and speakers at the MuscleX 2 Workshop.

BioCAT held its second MuscleX workshop course from 5/20/21-5/21/21. There were 149 remote participants and 11 speakers, consisting of 3 senior, 4 mid-career, 4 junior level researchers. The workshop was held entirely online, via BlueJeans, with a series of talk followed by general discussions in break-out sessions. The first day started with an introduction to BioCAT by Tom Irving followed by a comprehensive review of the muscle diffraction program at the BioCAT Beamline 18ID by Weikang Ma. The next talk was by Elisabetta Brunello (King’s College London) who described her studies, done at the ESRF in France, of myosin-based regulation mechanisms in rat cardiac muscle, showing among other things important …

more ...

Everything BioSAXS 7 Workshop Wrap-Up

BioCAT held its seventh intensive HOW-TO course in BioSAXS from 3/29/21-4/1/21 with 21 remote participants. There were four days of lectures and hands-on software tutorials on the basics of BioSAXS data collection and processing from expert practitioners in the field. Participants could elect to mail in samples for data collection prior to the course, and roughly half of them sent research samples and were able to analyze their own data as part of the workshop.
Participants and instructors at the Everything BioSAXS 7 Workshop.

BioCAT held its seventh BioSAXS training course from 3/29/21-4/1/21. There were 21 remote participants and 6 instructors. The workshop was held entirely online, via BlueJeans, for ~4 hours each day. Before the workshop started, participants were able to mail samples to BioCAT for SAXS data collection. This data was then sent to them, and they were able to analyze it as part of the workshop.

Day one started off with an excellent overview of the basic physics of SAXS and what kind of information you can obtain from the technique by Dr. Richard Gillilan (BioSAXS beamline, CHESS). This was followed by a talk from Dr. Jesse Hopkins …

more ...